The custom of illustrating anatomy by multi-layered flaps became widespread during the sixteenth century with 'Adam and Eve' plates. Remmelin's Catoptrum microcosmicum, first published at Ulm in 1619, though an unauthorized version without text had appeared in 1613, was the first anatomical atlas to be illustrated in this way. It consists of three full-page plates, engraved by Lucas Kilian (1579-1637) after Remmelin's drawings, with an accompanying text, index and portrait of Remmelin. It went through several editions in Latin, German, French, Dutch and English. The last edition was published in Verona in 1754. The Ulm editions of 1639 and 1660 were re-issues of the 1619 edition with cancel title pages.
